Mechanisms controlling the Th1/Th2 phenotype of a primary immune response are often discussed assuming that the generation of Th1 and Th2 cells from the common CD4 + precursor T helper (pTh) involves an interaction of this pTh cell with an antigen-presenting cell (APC) in the form of a two-cell inte
✦ LIBER ✦
Differentiation of CD4+ T Cells to Th1 Cells Requires MAP Kinase JNK2
✍ Scribed by Derek D Yang; Dietrich Conze; Alan J Whitmarsh; Tamera Barrett; Roger J Davis; Mercedes Rincón; Richard A Flavell
- Book ID
- 117722971
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 324 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1074-7613
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Upon antigenic stimulation, precursor CD4^+^ helper T‐cells differentiate into two subsets of effector cells, Th1 and Th2. These two subpopulations are defined by the pattern of cytokine expression that distinguishes these differentiated cells from their precursors. We have used reporter transgenic