Differentiation of abelson murine leukemia virus-infected promonocytic leukemia cells

✍ Scribed by David L. Hines

• Publisher: John Wiley and Sons
• Year: 1985
• Tongue: French
• Weight: 746 KB
• Volume: 36
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910360216

✦ Synopsis

Abstract

Virus‐producing, tumorigenic, promonocytic leukemia cell lines were derived from Abelson murine leukemia virus‐infected mice. This study shows that, of these 25 cloned lines, 22 were capable of extensive differentiation. It also shows that granulocyte‐macrophage colony‐stimulating activity increased the proportion of differentiating cells in 17/22 lines. Cells from agar colonies with a diffuse colony morphology had an increased expression of mature macrophage phenotypic characteristics, and a reduced proliferative capacity in vitro, compared to cells from agar colonies with a compact colony morphology. Cells from diffuse colonies also produced less Abelson virus, and were less tumorigenic in vivo than cells from compact colonies. Together, these results suggest some Abelson virus‐producing leukemic cells are not blocked in their capacity to differentiate and are capable of reversing the transformed phenotype.