✦ LIBER ✦

Isolation and characterization of Abelson murine leukemia virus-transformed mast cell lines from midgestation embryonic placenta

✍ Scribed by Michael L. Siegel; Randy Horwitz; Timothy D. Morris; Raina M. Di Venere; Edward J. Siden

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 733 KB
Volume: 15
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830151113

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✦ Synopsis

Abelson murine leukemia virus was used to transform cells of the midgestation embryonic placenta. The frequency of transformed foci in semisolid agarose was highest when cells were isolated at 10 days of gestation and cell lines could be established in liquid culture. The continuous cell lines express characteristics of cultured mast cells, including surface antigens which are shared with lymphocytes and mononuclear phagocytes. These results imply a relationship between the transforming gene product and the mast cell growth factor interleukin 3.

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✍ Michael M. Lieber; Charles J. Sherr; George J. Todaro 📂 Article 📅 1974 🏛 John Wiley and Sons 🌐 French ⚖ 882 KB

## Abstract A survey was undertaken to determine the prevalence of S‐tropic (xenotropic) murine type‐C viruses in continuous cell lines, leukemia virus preparations, and spleens of normal mice from various commonly used strains. Fifteen of 18 cell lines established from normal cells and transplanta