## Abstract 1,2โDisubstituted imidazoles react with phosphorus(III) halides in pyridine regioselectively at position 5. The reaction proceeds the more readily, the higher the electronโdonating ability of the 2โsubstituent in the starting imidazole. Hitherto unknown dihalo(imidazolโ5โyl)phosphines h
Differentiation of 1,4- and 1,5-disubstituted imidazoles
โ Scribed by Matthews, H. Randall.; Rapoport, Henry.
- Book ID
- 118137996
- Publisher
- American Chemical Society
- Year
- 1973
- Tongue
- English
- Weight
- 877 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0002-7863
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๐ SIMILAR VOLUMES
The synthesis of several 1H-imidazol-1-ylmethylpiperidines is described. A method for the regioselective isolation of 1,4-disubstituted imidazoles utilizing the selective quaternization of the 1,5-disubstituted regioisomer was developed.
## Abstract 4โSelenophosphorylโ1,2โdisubstituted imidazoles have been obtained by thermal decomposition of methyl 5โ(diamidoselenophosphoryl)imidazolium chlorides. The position of selenophosphoryl group in the imidazole ring was proved by ^1^H, ^13^C NMR spectroscopy, and Xโray analysis. Previously