Synthesis of substituted 1H-imidazol-1-ylmethylpiperidines. Facile separation of 1,4- and 1,5-disubstituted imidazoles

✍ Scribed by Jocelyn Rivera; Nilukshi Jayasuriya; Dinanath Rane; K. Keertikar; J.Albert Ferreira; Jianping Chao; Keith Minor; Timothy Guzi

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 187 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)02157-3

✦ Synopsis

The synthesis of several 1H-imidazol-1-ylmethylpiperidines is described. A method for the regioselective isolation of 1,4-disubstituted imidazoles utilizing the selective quaternization of the 1,5-disubstituted regioisomer was developed.