Differentiation between neurofibromas and malignant peripheral nerve sheath tumors in neurofibromatosis 1 evaluated by MRI
โ Scribed by Akihiko Matsumine; K. Kusuzaki; T. Nakamura; S. Nakazora; R. Niimi; T. Matsubara; K. Uchida; T. Murata; I. Kudawara; T. Ueda; N. Naka; N. Araki; M. Maeda; A. Uchida
- Publisher
- Springer-Verlag
- Year
- 2008
- Tongue
- English
- Weight
- 302 KB
- Volume
- 135
- Category
- Article
- ISSN
- 1432-1335
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Neurofibromatosis type 1 (NF1) patients have 10% of lifetime risk for developing malignant peripheral nerve sheath tumors (MPNST), one of the most aggressive cancers. We examined the spectrum of constitutional NF1 mutations among 24 NF1 patients with MPNST. We found mutations in 18 patients: four me
## Abstract Telomerase activity (TA) and the expression of its enzymatic subunits, which have been demonstrated in many tumors, remain poorly investigated in tumors associated with neurofibromatosis type 1 (NF1). In this study, we analysed the association of TA and the expression of telomerase RNA