Differentially expressed genes in neurofibromatosis 1-associated neurofibromas and malignant peripheral nerve sheath tumors
โ Scribed by Nikola Holtkamp; Victor-F. Mautner; ReinhardE. Friedrich; Anja Harder; Christian Hartmann; Agota Theallier-Janko; KarlT. Hoffmann; Andreas Deimling
- Publisher
- Springer-Verlag
- Year
- 2003
- Tongue
- English
- Weight
- 431 KB
- Volume
- 107
- Category
- Article
- ISSN
- 0001-6322
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Neurofibromatosis type 1 (NF1) patients have 10% of lifetime risk for developing malignant peripheral nerve sheath tumors (MPNST), one of the most aggressive cancers. We examined the spectrum of constitutional NF1 mutations among 24 NF1 patients with MPNST. We found mutations in 18 patients: four me
Cytogenetic studies in small groups of patients with malignant peripheral-nerve-sheath tumors (MPNST) revealed complex karyotypes with no consistent changes. A computerassisted cytogenetic analysis using a cytogenetic database was performed to determine recurrent cytogenetic alterations in 51 MPNSTs