✦ LIBER ✦

Differentiation and production of colony-stimulating factor induced by immunostimulants in a leukemia cell line

✍ Scribed by Michiyuki Maeda; Yasuo Ichikawa; Ichiro Azuma

Publisher: John Wiley and Sons
Year: 1980
Tongue: English
Weight: 453 KB
Volume: 105
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.1041050106

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Immunostimulants from various microorganisms were tested on a myeloid leukemia cell line (Ml) for the ability to induce production of CSF and to cause differentiation of these cells. Based on their activities, the compounds were divided into two general classes: those inducing extensive cellular differentiation and those devoid of this effect. The stimulants which were active in this regard always produced large quantities of CSF, whereas those devoid of a differentiating effect did not cause CSF production. Even the potent stimulants had no effect on the D^−^ subline, in which the differentiation was not inducible.

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