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Persistent production of colony-stimulating factor (CSF-1) by cloned bone marrow stromal cell line D2XRII after X-irradiation

✍ Scribed by Elizabeth Naparstek; Thomas Donnelly; Richard K. Shadduck; Abdul Waheed; Katherine Wagner; Kenneth R. Kase; Joel S. Greenberger

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
807 KB
Volume
126
Category
Article
ISSN
0021-9541

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Human bone marrow stromal cells repond to stimulation by the monokines IL-1 and TNF by producing colony-stimulating factors such as GM-CSF and G-CSF. In this study we show that I L -l a and TNFa act synergistically to stimulate GM-CSF and G-CSF production by cultured marrow stromal cells. We further