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Differentiation and migration of long term expanded human neural progenitors in a partial lesion model of Parkinson’s disease

✍ Scribed by Rowan M Burnstein; Tom Foltynie; Xiaoling He; David K Menon; Clive N Svendsen; Maeve A Caldwell


Book ID
116306684
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
372 KB
Volume
36
Category
Article
ISSN
1357-2725

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## Abstract Loss of the oligodendrocyte (OL)‐specific enzyme aspartoacylase (ASPA) from gene mutation results in the sponginess and loss of white matter (WM) in Canavan disease (CD). This study addresses the fate of OLs during the pathophysiology of CD in an adult ASPA knockout (KO) mouse strain. M