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Differentiation and Distributions of DNA/Cisplatin Crosslinks by Liquid Chromatography-Electrospray Ionization-Infrared Multiphoton Dissociation Mass Spectrometry

✍ Scribed by Xu, Zhe; Brodbelt, Jennifer S.


Book ID
121581677
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
893 KB
Volume
25
Category
Article
ISSN
1044-0305

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## Abstract Endogenous carcinogens arising from normal metabolism are known to cause modifications to DNA by reacting with bases to form adducts. Malondialdehyde is a well characterized endogenous carcinogen that forms an adduct with 2′‐deoxyguanosine. This adduct has been detected in rat and human