Differential use of Erk1/2 and transforming growth factor β pathways by mid- and late-gestational murine fibroblasts
✍ Scribed by Stephanie R. Goldberg; Gerald L. Quirk; Virginia W. Sykes; Robert P. McKinstry; Tomasz Kordula; David A. Lanning
- Book ID
- 116687115
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 403 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0022-3468
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Cyclin-dependent kinases (cdks) are a family of proteins whose function plays a critical role in cell cycle traverse. Transforming growth factor+, (TGF-P 1) is a potent growth inhibitor of epithelial cells. Since cdks have been suggested as possible biochemical markers for TGF-@ growth inhibition, w
## Abstract Basic fibroblast growth factor (bFGF) and transforming growth factor‐β1 (TGF‐β1) play an important role in proliferation, differentiation, and survival of malignant gliomas and in normal glial cell biology. Because of these critical roles, potential interactions between these key growth