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Differential stabilization of cytochrome P-450 isoenzymes in primary cultures of adult rat liver parenchymal cells

✍ Scribed by Dietmar Utesch; Elvira Molitor; Karl-Ludwig Platt; Franz Oesch


Book ID
112801614
Publisher
Society for In Vitro Biology
Year
1991
Tongue
English
Weight
929 KB
Volume
27
Category
Article
ISSN
1475-2689

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Liver primary cell cultures (LPCC) with decreasing concentrations of cytochrome P-450 were used to investigate the genotoxicity of the hepatic carcinogen dimethylnitrosamine (DMN) and the correlation between DMN genotoxicity and cytochrome P-450 levels. Hepatocytes were isolated from partially hepat