Differential sensitivity of hepatitis C virus quasispecies to interferon-α therapy
✍ Scribed by Masashi Mizokami; Johnson Y.N. Lau; Kaoru Suzuki; Tatsunori Nakano; Takashi Gojobori
- Book ID
- 118567232
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 744 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0168-8278
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W e quantified IgG antibodies to structural (core) and nonstructural (C100-3) hepatitis C virus proteins in 42 patients with chronic hepatitis C treated with a 6-mo course of interferon-a. Sera were drawn before and at the end of therapy and also 6 mo after therapy withdrawal; they were stored for l
Hepatitis C virus (HCV) appears to circulate in various forms such as native virion, immune complexes, and nucleocapsids during chronic infections. To determine the association of the physicochemical properties of HCV and its response to interferon therapy in patients with chronic hepatitis C, we ex