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Differential Sensitivity and Mechanism of Inhibition of COX-2 Oxygenation of Arachidonic Acid and 2-Arachidonoylglycerol by Ibuprofen and Mefenamic Acid

✍ Scribed by Prusakiewicz, Jeffery J.; Duggan, Kelsey C.; Rouzer, Carol A.; Marnett, Lawrence J.

Book ID: 118228912
Publisher: American Chemical Society
Year: 2009
Tongue: English
Weight: 660 KB
Volume: 48
Category: Article
ISSN: 0006-2960
DOI: 10.1021/bi900999z

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## Abstract Endocannabinoids (ECs), such as anandamide (AEA) and 2‐arachidonoylglycerol (2‐AG), modulate a number of physiological processes, including pain, appetite and emotional state. Levels of ECs are tightly controlled by enzymatic biosynthesis and degradation __in vivo__. However, there is l