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Design, synthesis, biological evaluation, and comparative Cox1 and Cox2 docking of p-substituted benzylidenamino phenyl esters of ibuprofenic and mefenamic acids

✍ Scribed by Gehan H. Hegazy; Hamed I. Ali


Book ID
113495651
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
843 KB
Volume
20
Category
Article
ISSN
0968-0896

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Fourteen new 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives were synthesized. Six compounds displayed potent inhibitory activities against COX-1/2 and 5-LOX with IC 50 in the range of 0.10-9.87 lM. Particularly, 10f exhibited well balanced inhibitory action on these enzymes (I