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Synthesis and Biologic Evaluation of Substituted 5-methyl-2-phenyl-1H-pyrazol-3(2H)-one Derivatives as Selective COX-2 Inhibitors: Molecular Docking Study

✍ Scribed by Dube, Pritam N.; Bule, Shweta S.; Mokale, Santosh N.; Kumbhare, Manoj R.; Dighe, Pravin R.; Ushir, Yogesh V.

Book ID: 121706369
Publisher: John Wiley and Sons
Year: 2014
Tongue: English
Weight: 809 KB
Volume: 84
Category: Article
ISSN: 1747-0277
DOI: 10.1111/cbdd.12324

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## Abstract Four series of 5‐methylsulfonyl‐1‐phenyl‐1__H__‐indole‐2‐carboxylic acid alkyl esters (family **A**), ‐2‐carbonitriles (family **B**), ‐2‐carboxamides (family **C**), and 2‐benzoyl‐5‐methylsulfonyl‐1‐phenyl‐1__H__‐indoles (family **D**) were prepared and evaluated for their ability to i