To preserve tissue integrity during the structural rearrangements that occur during central nervous system (CNS) development, an intricate balance between extracellular matrix (ECM) synthesis and degradation must be maintained. The matrix metalloproteinases (MMPs) are believed to be the main mediato
Differential regulation of TIMP-1, -2, and -3 mRNA and protein expressions during mouse incisor development
✍ Scribed by Nagako Yoshiba; Kunihiko Yoshiba; Corinne Stoetzel; Fabienne Perrin-Schmitt; Yves Cam; Jean Victor Ruch; Akihiro Hosoya; Hidehiro Ozawa; Hervé Lesot
- Publisher
- Springer-Verlag
- Year
- 2006
- Tongue
- English
- Weight
- 657 KB
- Volume
- 324
- Category
- Article
- ISSN
- 0302-766X
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## Abstract Matrix metalloproteinases (MMPs) are zinc‐dependent proteases capable of degrading extracellular matrix components. The activity of these proteases is tightly regulated through the actions of the tissue inhibitors of metalloproteinases (TIMPs). Although the regulation of MMPs and TIMPs
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