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Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases

✍ Scribed by Owens, D M; Keyse, S M


Book ID
110072410
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
199 KB
Volume
26
Category
Article
ISSN
0950-9232

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Increased mitogen-activated protein kinase (MAPK) activity correlates with a more malignant hepatocellular carcinoma (HCC) phenotype. There is a reciprocal regulation between p44/42 MAPK (extracellular signal-regulated kinase [ERK]1/2) and the dual-specificity MAPK phosphatase MKP-1/DUSP1. ERK phosp