The human telomerase reverse transcriptase (TERT) gene is transcriptionally inactivated in most differentiated cells but is reactivated in the majority of cancer cells. To elucidate how TERT is inactivated during differentiation, we applied all-trans retinoic acid (ATRA) to induce the differentiatio
✦ LIBER ✦
Differential regulation of human and mouse telomerase reverse transcriptase (TERT) promoter activity during testis development
✍ Scribed by J.M. Weise; Ç. GüneŞ
- Book ID
- 111664491
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 532 KB
- Volume
- 76
- Category
- Article
- ISSN
- 1040-452X
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Telomerase is an enzyme activity consisting of a reverse transcriptase called TERT and an RNA component that adds repeats of a DNA sequence (TTAGGG) to the ends of chromosomes, thereby preventing their shortening. Associations between telomerase activity and proliferation and differentiation of neur