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Differential regulation by cytokines of human astrocyte nitric oxide production

✍ Scribed by Shuxian Hu; Wen S. Sheng; Phillip K. Peterson; Dr. Chun C. Chao

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
403 KB
Volume
15
Category
Article
ISSN
0894-1491

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✦ Synopsis

Reactive nitrogen intermediates, such as nitric oxide (NO), play an important role in host-defense and injury. Human astrocytes released abundant NO upon stimulation with the pro-inflammatory cytokine interleukin (IL)-lp, which was potentiated by interferon (1FN)-y and tumor necrosis factor (TNFI-a. IL-1 receptor antagonist protein markedly attenuated astrocyte NO production. The anti-inflammatory cytokines IL-4 and IL-10 potently suppressed IL-113 plus IFN-y-stimulated NO, while

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