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Differential recognition of sequences within the encephalitogenic region of myelin basic protein capable of eliciting cell-mediated immune responses in experimental autoimmune encephalomyelitis

✍ Scribed by M.K.H. Malotky; P.Y. Paterson; S.D. Miller


Book ID
119108791
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
59 KB
Volume
51
Category
Article
ISSN
0165-5728

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Studies from our laboratory have shown that region 69-84 (synthetic peptide S49S) of myelin basic protein (MBP) defines an encephalitogenic sequence for experimental allergic encephalomyelitis (EAE) in Lewis rats. The most potent EAE inducers are the guinea pig MBP (Gp-MBP) and region 69-84, known a