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Differential modulation of cisplatin and doxorubicin efficacies in leukemia cells by flavonoids

✍ Scribed by Luboš Čipák; Ladislav Novotný; Ingrid Čipáková; Peter Rauko


Book ID
117442454
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
444 KB
Volume
23
Category
Article
ISSN
0271-5317

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## Abstract We studied the restoration of doxorubicin accumulation and sensitivity by verapamil and quinine in a variant of the human erythroleukemia cell line K562 selected for resistance to doxorubicin and presenting a multidrug‐resistance (MDR) phenotype. Verapamil was able to completely restore