Modulation of cell growth and cisplatin sensitivity by membrane γ-glutamyltransferase in melanoma cells
✍ Scribed by Maria Franzini; Alessandro Corti; Evelina Lorenzini; Aldo Paolicchi; Alfonso Pompella; Michelandrea De Cesare; Paola Perego; Laura Gatti; Roberto Leone; Pietro Apostoli; Franco Zunino
- Book ID
- 116429022
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 366 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0959-8049
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Glutathione plays an important role in drug resistance of tumor cells and in their ability to resist oxidative stress. Improved salvage of glutathione can be obtained through increased activity of ␥-glutamyltransferase (GGT), which is of importance in the maintenance of cellular glutathione homeosta
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