Differential inhibition of human secretory and cytosolic phospholipase A2
✍ Scribed by F. Märki; W. Breitenstein; E. Beriger; R. Bernasconi; G. Caravatti; J. E. Francis; R. Paioni; H. U. Wehrli; R. Wiederkehr
- Publisher
- SP Birkhäuser Verlag Basel
- Year
- 1993
- Tongue
- English
- Weight
- 628 KB
- Volume
- 38
- Category
- Article
- ISSN
- 1420-908X
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Melittin and phospholipase A 2 -activating protein (PLAP) are known as efficient activators of secretory phospholipase A 2 (sPLA 2 ) types I, II, and III when phospholipid liposomes are used as substrate. The present study demonstrates that both peptides can either inhibit or activate sPLA 2 dependi
## Abstract A secreted form of phospholipase A~2~ (PLA~2~) is thought to play an important role in inflammatory diseases. To characterize this enzyme the cDNA encoding a low molecular weight PLA~2~ was cloned from a human placental cDNA library. The cDNA encoding the human PLA~2~ was subcloned into