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Differential induction of Epstein-barr virus-related antigens in human lymphoblastoid cells by virus-mediated cell-to-cell contact

✍ Scribed by T. Matsuo; K. Yamamoto; T. Osato

Publisher
John Wiley and Sons
Year
1976
Tongue
French
Weight
533 KB
Volume
17
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Differential induction of Epstein‐Barr virus (EBV)‐related antigens was observed after Sendai virusmediated fusion of producer and non‐producer cells with various human and mouse cells. The EBV‐determined early nuclear antigen (ENA), early antigen (EA) and viral capsid antigen (VCA) could be induced at a high rate in producer cells (P3HR‐1 and B95–8), normally expressing these antigens at very low frequency, as early as 12–24 h after fusion with each other or with human amnion FL cells. In contrast, only one antigen, ENA, was induced in producer cells following fusion with non‐producer cells. This limited induction occurred also in non‐producer cells fused with FL cells, but not after fusion with each other. EBV induction did not result from fusion of either producer or non‐producer cells with mouse cells (L‐M (TK^‐^) Cl1D and MCB‐6). The differential induction was not the result of heterokaryon formation as determined by autoradiography. The implications of these findings are discussed.

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