Differential immunostimulating effect of Granulocyte-macrophage colony-stimulating factor (GM-CSF), Granulocyte colony-stimulating factor (G-CSF) and Interferon γ (IFNγ) after severe trauma
✍ Scribed by S. Lendemans; E. Kreuzfelder; C. Waydhas; F. U. Schade; S. Flohé
- Publisher
- SP Birkhäuser Verlag Basel
- Year
- 2007
- Tongue
- English
- Weight
- 602 KB
- Volume
- 56
- Category
- Article
- ISSN
- 1420-908X
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Granulocyte-macrophage colony-stimulating factor (GM-CSF) (250 microg/m2) was administered subcutaneously to 7 normal volunteers for up to 14 days to study its effects on neutrophil kinetics and function. With treatment, blood neutrophil counts rose gradually to peak at 3 1/2 times baseline by day 1
A therapeutic trial of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) was attempted in a patient with neutropenia and frequent infections secondary to T-y lymphoproliferative disease (T-y LPD). During the 14 days of subcutaneous rhGM-CSF (500 kg/m2/day), the absolute e