Differential genetic determination of immune responsiveness to hepatitis B surface antigen and to hepatitis A virus: a vaccination study in twins
✍ Scribed by Thomas Höhler; Esther Reuss; Nina Evers; Evi Dietrich; Christian Rittner; Christine M Freitag; Jens Vollmar; Peter M Schneider; Rolf Fimmers
- Book ID
- 117281714
- Publisher
- The Lancet
- Year
- 2002
- Tongue
- English
- Weight
- 120 KB
- Volume
- 360
- Category
- Article
- ISSN
- 0140-6736
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Abbreviations: HBsAg, hepatitis B surface antigen; anti-HBs, hepatitis B surface antimonths. 2 From the 415 children, we recruited 16 chronically infected gen antibody; HBV, hepatitis B virus; PCR, polymerase chain reaction; PBMC, peripheral children who had cleared serum HBsAg for more than 2 years
Recent data suggest that genes involved in the control of (1) immune responses of humans to HBsAg and (2) the susceptibility to the development of chronic hepatitis B are linked to the major HLA histocompatibility complex. Studies on the genetic regulation of anti-HBs responses and on the possible a