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Differential expression of thymosin genes in human tumors and in the developing human kidney

✍ Scribed by Alan K. Hall

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
715 KB
Volume
48
Category
Article
ISSN
0020-7136

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✦ Synopsis

Thymosins p4 and plo are 2 structurally related polypeptides originally defined in the rat immune system. To date, no truly unambiguous functions have been formally ascribed to these small (<4.9 kDa) acidic proteins. Previous research has demonstrated relationships between expression of these genes and cell growthldifferentiation. These observations prompted the present study which has used cDNA and synthetic oligonucleotide probes in combination with highperformance liquid chromatography (HPLC) to examine the differential expression of these 2 genes in normal and neoplastic human tissues and in the developing human kidney.

Low levels of p4 and plo mRNA species prevailed in normal tissues; in contrast, these gene transcripts were notably more abundant in malignant renal tumors and in the normal human embryonic kidney. These findings show that the thymosin p, and plo genes are constitutively expressed at higher levels in embryonidneoplastic as compared to normallbenign tissues and that thymosin in plo in particular may be a new molecular marker for renal-cell carcinoma as well as other malignancies.

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