Differential expression of oncogenic miRNAs in proliferating and senescent human fibroblasts
β Scribed by Miao Wang; Zhaojie Cheng; Tian Tian; Jingwen Chen; Fei Dou; Mingzhou Guo; Yu-Sheng Cong
- Publisher
- Springer
- Year
- 2011
- Tongue
- English
- Weight
- 547 KB
- Volume
- 352
- Category
- Article
- ISSN
- 0300-8177
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Upregulation of the p16 tumor suppressor is a hallmark of senescence in human fibroblasts. In this study, we investigated potential protein modification of p16 in senescent human fibroblasts using 2D SDSβPAGE analysis. Three distinct p16 variants with isoelectric points of 5.2, 5.4, and
## Abstract Peptide production in senescent and presenescent human foreskin fibroblasts was measured using 2βdimensional polyacrylamide gel electrophoresis. This procedure permits the visualization of a cohort of the major peptides being produced. Among this cohort of over 500 peptides only two wer
An E-box (CACGTG) designer microarray was developed to monitor a group of genes whose expressions share a particular regulatory mode. Sensitivity and specificity of microarray hybridization, as well as variability of microarray data, were evaluated. This designer microarray was used to generate expr
Temporal variations in the expression of the __ras__ oncogene, and its protein product, were investigated during hexamethylene bisacetamide (HMBA)βinduced differentiation of murine erythroleukaemic (MEL) cells. We highlight the fact that when comparisons were made between untreated, proliferating ce