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Differential expression of mRNAs detected by cDNA microarrays in Alzheimer's disease

✍ Scribed by Makoto Masumura; Ryuji Hata; Hiroyasu Akatsu; Takayuki Yamamoto; Hidechika Okada; Kenji Kosaka; Yasuo Nagai; Tohru Sawada

Book ID
117411220
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
190 KB
Volume
21
Category
Article
ISSN
0197-4580

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In both trisomy 21 and rare cases of triplication of amyloid precursor protein (APP) Alzheimer's disease (AD) pathological changes are believed to be secondary to increased expression of APP. We hypothesized that sporadic AD may also be associated with changes in transcription of APP or its metabol