Development of complex organisms requires specific temporospatial differentiation and expression of the correct phenotype through activation of a variety of genes. Galectins are mammalian lectins able to interact with various extracellular matrix glycoconjugates and have been implicated in several b
Differential expression of galectin 3 and galectin 1 in colorectal cancer progression
β Scribed by X Sanjuan; PL Fernandez; A Castells; V Castronovo; F van den Brule; FT Liu; A Cardesa; E Campo
- Book ID
- 118519717
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 677 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0016-5085
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## Abstract Galectins constitute a family of 15 mammalian galactosideβbinding proteins that share a consensus amino acid sequence in their carbohydrate binding sites. They are multiβfunctional molecules and are expressed widely in human tissues. Four galectins: galectin β1, β3, β4 and β8 are expres
Galectin-1 and galectin-3 are galactoside-binding proteins involved in different steps of tumor progression and potential targets for therapy. We have investigated the expression of these galectins in 38 human bladder transitional-cell carcinomas of different histological grade and clinical stage an