𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The role of galectins in colorectal cancer progression

✍ Scribed by Hannah Barrow; Jonathan M. Rhodes; Lu-Gang Yu

Publisher
John Wiley and Sons
Year
2011
Tongue
French
Weight
291 KB
Volume
129
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Galectins constitute a family of 15 mammalian galactoside‐binding proteins that share a consensus amino acid sequence in their carbohydrate binding sites. They are multi‐functional molecules and are expressed widely in human tissues. Four galectins: galectin βˆ’1, βˆ’3, βˆ’4 and βˆ’8 are expressed in the human colon and rectum and their expressions show significant changes during colorectal cancer development and metastasis. These changes in galectin expression correlate with alterations in cancer cell growth, apoptosis, cell–cell and cell–matrix interactions and angiogenesis. This review summaries current knowledge of the expression and roles of these galectins in the progression of human colorectal cancer and discusses the relevance of galectins and their ligands as potential therapeutic targets for cancer treatment.

πŸ“œ SIMILAR VOLUMES

The role of trophinin, an adhesion molec
The role of trophinin, an adhesion molecule unique to human trophoblasts, in progression of colorectal cancer
✍ Oi Harada; Tomoaki Suga; Takefumi Suzuki; Katsuaki Nakamoto; Motohiro Kobayashi; πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 French βš– 447 KB

## Abstract Trophinin is a unique adhesion molecule expressed by human trophoblastic cells. Its activity and __in vivo__ expression pattern implicate trophinin in the initial attachment of trophectoderm cells to maternal epithelia. Subsequent to apical adhesion, trophoblasts aggressively invade mat

Prognostic role of tumour fixity in colo
Prognostic role of tumour fixity in colorectal cancer
✍ D. J. Galloway; H. J. G. Burns; R. K. S. Phillips; H. A. F. Dudley πŸ“‚ Article πŸ“… 1983 πŸ› John Wiley and Sons 🌐 English βš– 151 KB πŸ‘ 2 views
The role of the disintegrin metalloprote
The role of the disintegrin metalloproteinase ADAM15 in prostate cancer progression
✍ Neali Lucas; Mark L. Day πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 152 KB

## Abstract The metalloproteinase ADAM15 is a multi‐domain disintegrin protease that is upregulated in a variety of human cancers. ADAM15 mRNA and protein levels are increased in prostate cancer and its expression is significantly increased during metastatic progression. It is likely that ADAM15 su