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Differential expression of dendritic cell markers by all-trans retinoic acid on human acute promyelocytic leukemic cell line

✍ Scribed by Hae-Young Park; Ji-Yeon Park; Ja-Woong Kim; Min-Jung Lee; Min-Jung Jang; Sun-Young Lee; Dae-Won Baek; Yeong-Min Park; Sang-Wha Lee; Sik Yoon; Yoe-Sik Bae; Jong-Young Kwak


Book ID
116575625
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
630 KB
Volume
4
Category
Article
ISSN
1567-5769

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Phosphatidic acid induces the differenti
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## Abstract We investigated whether phosphatidic acid (PA) can differentiate the promyelocytic leukemia (PML)‐retinoic acid receptor Ξ± (RARΞ±)‐expressing acute promyelocytic leukemic cell line, NB4, to dendritic cell (DC)‐like cells. Dioctanoyl‐PA alone upregulated the expression of DC markers. The