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45. Regulation of BcI-2 and cell death by all-trans retinoic acid in acute promyelocytic leukemic cells

โœ Scribed by Chomiennc, C; Barbey, S; Balitrand, N; Degos, L; Sachs, L

Book ID
123250585
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
117 KB
Volume
46
Category
Article
ISSN
0753-3322

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Differentiation therapy with all-trans retinoic acid (ATRA) has been used successfully to treat acute promyelocytic leukemia (APL), but such treatment also causes differentiation syndrome (DS) by inducing APL cell infiltration into alveolar spaces. The mechanism underlying the clearance of infiltrat