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Differential expression of Bcl-2, Bax, and CD95 in DNA repair-proficient and DNA repair-deficient basal cell carcinoma patients

✍ Scribed by K. Abid; B. Fazaa; Ch. Hadouchi; F. El Mezni; M. R. Kamoun; K. Hamzaoui


Book ID
110877926
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
157 KB
Volume
45
Category
Article
ISSN
0011-9059

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We examined the p53 status of 108 NSCLCs compared to the expression of MLH1 and MSH2 proteins. p53 overexpression was demonstrated by IHC in 64% of patients examined, whereas p53 mutations were detected in 43%. Twenty-two percent of mutations were located outside of the hot-spot (exons 5-8) area. p5