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Differential expression and regulation of cyclooxygenase-2 in colorectal cancer cells

โœ Scribed by Katherine M. Sheehan; Desmond J. Fitzgerald; Frank E. Murray

Book ID
119425417
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
185 KB
Volume
118
Category
Article
ISSN
0016-5085

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Both the matrix metalloproteinase matrilysin and the prostaglandin H synthase cyclooxygenase-2 (Cox-2), are thought to play key roles in colorectal carcinogenesis. These enzymes are overexpressed in 85-90% of human colorectal cancers. Furthermore, mice carrying an adenomatous polyposis coli germline