𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Differential effects on T cell and NK cell development by tissue-specific expression of H-2Dd transgene

✍ Scribed by Maria H. Johansson; Charles Bieberich; Anna Kåse-Sjöström; Takayuki Yoshioka; Elin Höglund; Barbara A. Christy; George Scangos; Klas Kärre; Gilbert Jay; Petter Höglund

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
123 KB
Volume
30
Category
Article
ISSN
0014-2980

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Cytokine regulation of IL-12 receptor β2
Cytokine regulation of IL-12 receptor β2 expression: differential effects on human T and NK cells
✍ Chang-You Wu; Massimo Gadina; Kening Wang; John O'Shea; Robert A. Seder 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 234 KB 👁 1 views

The biological activities of IL-12 are mediated through a specific, high-affinity receptor composed of IL-12 receptor(R)beta1 and IL-12Rbeta2 subunits that exist primarily on T and NK cells. Remarkably, the expression of IL-12Rbeta2 on CD4(+) T cells in mouse and humans appears to be differentially

α1 / α2 domains of H-2Dd, but not H-2Ld,
α1 / α2 domains of H-2Dd, but not H-2Ld, induce “missing self” reactivity in vivo – No effect of H-2Ld on protection against NK cells expressing the inhibitory receptor Ly49G2
✍ Maria H. Johansson; Elin Höglund; Mary C. Nakamura; James C. Ryan 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 141 KB

Introduction of the MHC class I transgene H-2D d on C57BL/6 (B6) background conveys NK cell-mediated "missing self" reactivity against transgene-negative cells, and down-regulates expression of the inhibitory receptors Ly49A and Ly49G2 in NK cells. We here present an analysis of transgenic mice expr