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Differential effects of rapamycin, cyclosporine A, and FK506 on human coronary artery smooth muscle cell proliferation and signalling

✍ Scribed by Sassan Hafizi; Vanessa N. Mordi; Klara M. Andersson; Adrian H. Chester; Magdi H. Yacoub

Book ID
113951214
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
504 KB
Volume
41
Category
Article
ISSN
1537-1891

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## Abstract Platelet‐derived growth factor (PDGF) has been implicated in smooth muscle cell (SMC) proliferation, a key event in the development of myointimal hyperplasia in vascular grafts. Recent evidence suggests that the PDGF receptor (PDGFR) tyrosine kinase inhibitor, imatinib, can prevent arte