Differential effects of intermittent and continuous administration of parathyroid hormone on bone histomorphometry and gene expression
β Scribed by Sutada Lotinun; Jean D. Sibonga; Russell T. Turner
- Book ID
- 111637734
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 336 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0969-711X
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To evaluate the potential use of a combination of parathyroid hormone (PTH) and estrogen as therapy for osteoporosis, we examined the effects of combined and separate administration of low-dose PTH and estradiol in ovariectomized rats with established osteopenia. Ovariectomized rats were untreated f
## Abstract Parathyroid hormone (PTH) has biphasic effects on bone: continuous treatment is catabolic whereas intermittent treatment is anabolic. The mechanism(s) responsible for these differing effects are still unclear, partly because of the previous nonβavailability of a model system in which ef
## Abstract ## Objective To investigate the effect of intermittent administration of human parathyroid hormone (PTH) on bone mineral density (BMD) and arthritis in rats with collagenβinduced arthritis (CIA). ## Methods Sevenβmonthβold female SpragueβDawley rats were divided into 4 groups: rats w