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Differential effects of interferon on ventromedial hypothalamus and dorsal hippocampus

✍ Scribed by B. Prieto-Gomez; C. Reyes-Vazquez; N. Dafny

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 369 KB
Volume: 10
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.490100305

No coin nor oath required. For personal study only.

✦ Synopsis

Three incremental doses of recombinant a-interferon (IF) were applicd iontophoretically to hippocampal and hypothalamic cells. IF produced a dosc-dependent long-lasting excitation in hippocanipal neurons, whereas, in the hypothalamus 01-IF elicited biphasic responses. The highest IF currents induced changes in the amplitude of the action potentials on both structures. Our observations suggest that IF could have a selective effect on the specific areas studied.

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