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Differential effects of chronic ethanol exposure on cytochrome P450 2E1 and the hypothalamic–pituitary–adrenal axis in the maternal–fetal unit of the guinea pig

✍ Scribed by Amy J. Hewitt; Kevin R. Walker; Susan M. Kobus; Margo Poklewska-Koziell; James N. Reynolds; James F. Brien


Book ID
113825632
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
347 KB
Volume
32
Category
Article
ISSN
0892-0362

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The release of proinflammatory cytokines by endotoxins and during oxidative stress is considered to be an early key step in the pathogenesis of alcoholic liver disease (ALD). Ethanol-inducible cytochrome P450 2E1 (CYP2E1) has potentially pro-oxidative and toxicological properties, and its expression