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Differential Cytotoxicity of Human Wild Type and Mutant α-Synuclein in Human Neuroblastoma SH-SY5Y Cells in the Presence of Dopamine †

✍ Scribed by Moussa, Charbel E.-H.; Wersinger, Christophe; Tomita, York; Sidhu, Anita

Book ID
127245189
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
337 KB
Volume
43
Category
Article
ISSN
0006-2960

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## Abstract Free cytoplasmic dopamine may be involved in the genesis of neuronal degeneration in Parkinson's disease and other such diseases. We used SH‐SY5Y human neuroblastoma cells to study the effect of dopamine on cell death, activation of stress‐induced pathways, and expression of α‐synuclein