Differential binding patterns of monoclonal antibody 2C4 to the ErbB3–p185her2/neu and the EGFR–p185her2/neu complexes
✍ Scribed by Cai, Z; Zhang, G; Zhou, Z; Bembas, K; Drebin, J A; Greene, M I; Zhang, H
- Book ID
- 109970446
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 230 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0950-9232
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Over‐expression of the c‐__erb__B‐2 (HER‐2/__neu__) gene product p185 occurs in 30% of breast and ovarian cancers. The p185 protein might serve as a target for serotherapy in that antibodies against different epitopes on the extracellular domain of p185 can inhibit growth of tumor cells
Different epitopes on the extracellular domain of the HER-2 receptor can serve as distinct targets for immunotoxins. To determine the optimal epitope target for immunotoxin therapy, 7 anti-HER-2 ricin A chain murine monoclonal immunotoxins, each reactive with different epitopes of HER-2 receptor, we