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Differential anti-inflammatory effects of immunosuppressive drugs: Cyclosporin, rapamycin and FK-506 on inducible nitric oxide synthase, nitric oxide, cyclooxygenase-2 and PGE2production

✍ Scribed by M. G. Attur, R. Patel, G. Thakker, P. Vyas, D. Levartovsky, P. Patel, S. Naqvi, R. Raza, K. Patel, D. Abramson, G. Bruno, S. B. Abramson, A. R. Amin


Book ID
113011117
Publisher
SP Birkhäuser Verlag Basel
Year
2000
Tongue
English
Weight
275 KB
Volume
49
Category
Article
ISSN
1420-908X

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## Abstract The inhibitory effects of inotilone and methylinotilone on the induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase‐2 (COX‐2) in murine RAW 264.7 cells activated with LPS were investigated. The results show that both hydroxyl groups on the benzene ring of the inotilone