A novel indazolo-triazolo-benzotriazepine exerts anti-inflammatory effects by inhibition of cyclooxygenase-2 activity and nitric oxide synthase-2 expression

Inhibition of lipopolysaccharide-induced

Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 gene expression by 5-aminoimidazole-4-carboxamide riboside is independent of AMP-activated protein kinase

✍ Chih-Lin Kuo; Feng-Ming Ho; Mei Ying Chang; Ekambaranellore Prakash; Wan-Wan Lin 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 311 KB

## Abstract Recent studies suggest AMP‐activated protein kinase (AMPK), an enzyme involved in energy homeostasis, might be a novel signaling pathway in regulating inflammatory response, but the precise intracellular mechanisms are not fully understood. In this study, we have demonstrated that 5‐ami