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Differential activation of the PI 3-kinase effectors AKT/PKB and p70 S6 kinase by compound 48/80 is mediated by PKCα

✍ Scribed by Richard D. Byrne; Erika Rosivatz; Maddy Parsons; Banafshé Larijani; Peter J. Parker; Tony Ng; Rudiger Woscholski


Book ID
113528009
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
961 KB
Volume
19
Category
Article
ISSN
0898-6568

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The antiapoptotic effect of guanosine is
✍ Patrizia Di Iorio; Patrizia Ballerini; Ugo Traversa; Ferdinando Nicoletti; Iolan 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 309 KB 👁 1 views

## Abstract Guanosine has many trophic effects in the CNS, including the stimulation of neurotrophic factor synthesis and release by astrocytes, which protect neurons against excitotoxic death. Therefore, we questioned whether guanosine protected astrocytes against apoptosis induced by staurosporin