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Different properties of the central and peripheral forms of human tryptophan hydroxylase

โœ Scribed by Jeffrey McKinney; Per M. Knappskog; Jan Haavik

Book ID
111178622
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
191 KB
Volume
92
Category
Article
ISSN
0022-3042

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Functional properties of missense varian
Functional properties of missense variants of human tryptophan hydroxylase 2
โœ Jeffrey A. McKinney; Banu Turel; Ingeborg Winge; Per M. Knappskog; Jan Haavik ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 231 KB

Tryptophan hydroxylase 2 (TPH2) catalyzes the rate-limiting step in serotonin biosynthesis in the nervous system. Several variants of human TPH2 have been reported to be associated with a spectrum of neuropsychiatric disorders such as unipolar major depression, bipolar disorder, suicidality, and att