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Characterization of wild-type and mutant forms of human tryptophan hydroxylase 2

โœ Scribed by Ingeborg Winge; Jeffrey A. McKinney; Per M. Knappskog; Jan Haavik


Book ID
111179917
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
731 KB
Volume
100
Category
Article
ISSN
0022-3042

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Functional properties of missense varian
โœ Jeffrey A. McKinney; Banu Turel; Ingeborg Winge; Per M. Knappskog; Jan Haavik ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 231 KB

Tryptophan hydroxylase 2 (TPH2) catalyzes the rate-limiting step in serotonin biosynthesis in the nervous system. Several variants of human TPH2 have been reported to be associated with a spectrum of neuropsychiatric disorders such as unipolar major depression, bipolar disorder, suicidality, and att