Different immunogenetic background in autoimmune hepatitis type 1, type 2 and autoimmune sclerosing cholangitis
β Scribed by James A. Underhill; Yun Ma; Dimitrios P. Bogdanos; Paul Cheeseman; Giorgina Mieli-Vergani; Diego Vergani
- Book ID
- 118565480
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 118 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0168-8278
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Children with primary sclerosing cholangitis or autoimmune chronic active hepatitis have similar high levels of immunoglobulin G and non-organ-specific autoantibodies and may have similar histological features. To investigate a possible immunopathogenesis of primary sclerosing cholangitis, we have s
Perinuclear anti-neutrophil cytoplasmic antibodies (pANCA) have been recently defined as the most sensitive autoantibody of type 1 autoimmune hepatitis (AIH-1). Their prevalence in type 2 autoimmune hepatitis (AIH-2) has not yet been evaluated. The aim of the present study was to verify the associat
## Abstract Sera from 14 patients with type 2 autoimmune hepatitis (antiβLKM, positive) were investigated for evidence of hepatitis C virus (HCV) infection. Antibodies to HCV were detected in 13 patients by both commercial and βinβhouseβ ELlSAs and also by a second generation recombinant immunoblot